Chromatin Condensation and Apoptosis

Y Hu, Z Liu, S-J Yang and K Ye report in an article titled Acinus-provoked protein kinase C isoform activation is essential for apoptotic chromatin condensation, which is published in Cell Death and Differentiation, (14, 2035–2046; published online 24 August 2007) that there is a close correlation between Histone H2B phosphorylation and chromatin condensation during apoptosis. Chromatin condensation is provoked in the nucleus by caspase-cleaved acinus. Acinus is an acronym for- apoptotic chromatin condensation inducer in the nucleus.